The Carlisle Area School District serves students from Carlisle as well as other local townships. The varying areas that the district serves provides a unique setting of both urban and rural environments that helps to create a culturally diverse student body. The district has been recognized for its excellence in academics. For example, School Match, a leading national relocation firm, awarded the district with its “What Parents Want Award” for eight consecutive years.

Higher educational opportunities are found both in and near Carlisle. Dickinson College, Penn State University’s Dickinson School of Law and the U.S. Army War College are all located within Carlisle. Other nearby institutions include Shippensburg University, Penn State - Capital Campus, Wilson College, Gettysburg College and the Harrisburg Area Community College.

In addition to excellent schools, Carlisle provides many park facilities and recreational programs for residents at 14 local parks that feature athletic fields, playgrounds and nature trails. The Carlisle Community Center features a community pool and several activities for all ages. There is also an Amphitheater that plays host to numerous events during the year.

The Borough of Carlisle was laid out and settled by Scots-Irish immigrants in 1751. During its earliest period, Carlisle was situated near major Indian hunting grounds and warpaths. The name "Carlisle" was selected after its namesake, the county seat of Cumberland County in England. In the French and Indian War, Carlisle was the western point at which British Crown regiments bivouacked. As early as the Colonial period, Carlisle was the major jumping-off point for travel west to the Ohio Valley, and it has continued to be a crossroad of national importance with its close proximity to the Pennsylvania Turnpike and Interstate 81.